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In detail, ROS are involved in disturbing antioxidant defenses, the mitochondria, microtubule, ion channels, and biomolecular functions, as well as inducing neuroinflammation, demyelination, and neuronal apoptosis in the process of PIPN (Areti et al., 2014)

Abstract Oxidative stress (OS) is crucial in schizophrenia (SCZ) pathology

IGFBP3 epigenetic promotion induced by METTL3 boosts cardiac fibroblast activation and fibrosis